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Northeast (NYC, Boston, DC)
New York City, Boston, Washington DC, Philadelphia, Niagara Falls
Dense, walkable, train-connected (Amtrak Boston-NYC-DC). The most European-feeling region. Best weather May–June and September–October; brutal humid summers, snowy winters. NYC + DC + Boston in 10 days is the classic East-Coast trip.
Southwest (Vegas, Grand Canyon, Sedona)
Las Vegas, Grand Canyon, Zion, Bryce, Antelope Canyon, Sedona, Monument Valley
Red rock + desert landscape = the most photographable region. Fly into Las Vegas (LAS), rent a car, do a 7–10-day national parks loop. Best March–May and September–November; brutal 45°C heat in summer at low elevations.
West Coast (California)
San Francisco, Yosemite, Big Sur, LA, San Diego, Napa
Pacific Coast Highway is the spine — drive SF to LA over 3 days. Yosemite 3 hours east of SF. Napa Valley 1hr north for wine. Year-round mild; cool foggy summer mornings in SF, hot dry in the LA area.
Pacific Northwest
Seattle, Portland, Mount Rainier, Olympic NP, Crater Lake
Rainy, green, mountains-and-coast. Seattle (Pike Place Market, Space Needle), Portland (food carts, breweries), Mount Rainier glaciers, Olympic rainforest. Best June–September; rain other 9 months. Coffee culture is the densest in the country.
South (New Orleans, Nashville)
New Orleans, Nashville, Memphis, Charleston, Savannah, Atlanta
Music + food + history. New Orleans for jazz and Creole; Nashville for country; Memphis for blues and barbecue; Charleston and Savannah for antebellum-era cobblestone old towns. Hot humid summers; perfect spring and fall.
Hawaii & Alaska (off-grid)
Maui, Oahu, Big Island, Kauai · Anchorage, Denali, Juneau
Detached from the mainland (5-hour flight from West Coast). Hawaii is tropical, year-round-warm, multi-island. Alaska is wild, glaciers + grizzlies + Denali, only viable May–September. Both are separate trips, not add-ons.